Polly and Molly (Born 1997 - 2000), two ewes, were the first mammals to have been successfully cloned from an adult somatic cell and to be transgenic animals at the same time. This could hopefully be used to produce pharmacological and therapeutic proteins to treat human diseases. Dolly the sheep, as the first mammal to be cloned from an adult cell, is by far the world's most famous clone. CLONING!
Note the transgenic, humanized sheep clone: Blue eyes, human hair, human nose, an affectation for boots. The first study to review the long-term health outcomes of cloning, the authors found no evidence of late-onset, non-communicable diseases other than some minor examples of osteoarthritis and concluded "We could find no evidence, therefore, of a detrimental long-term effect of cloning by SCNT on the health of aged offspring among our cohort. The protein in question was the human blood clotting Prior to the production of Polly and Molly, the only demonstrated way to make a transgenic animal was by In mice, there is an additional option for genetic transfer that is not available in other animals. Dolly was a female domestic sheep, and the first mammal cloned from an adult somatic cell, using the process of nuclear transfer. The announcement in February 1997 of Dolly’s birth marked a milestone in In terms of laboratory cloning, transgenic frogs, mice and cows have been available from the 1980s onwards. The transgene that was inserted in the donor somatic cells was designed to express human clotting Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts, AE Schnieke et al. Scientists used cells into which a new gene had been inserted so that the animals produced a therapeutic protein in their blood.
There is no difference in mortality between transgenic sheep and non-transgenic sheep, which indicated lentiviral transgenesis has no obvious disturbance on development of transgenic sheep. Read what you need to know about our industry portal bionity.com.Find out more about the company LUMITOS and our team.Find out how LUMITOS supports you with online marketing.© 1997-2020 LUMITOS AG, All rights reservedhttps://www.bionity.com/en/encyclopedia/Polly_and_Molly.html
Dolly, female Finn Dorset sheep that lived from 1996 to 2003, the first clone of an adult mammal, produced by British developmental biologist Ian Wilmut and colleagues of the Roslin Institute, near Edinburgh, Scotland.
PPL's scientists have cloned sheep before - not only Dolly but nine others using other techniques.
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